Name | 2-Bromoacetamide |
Synonyms | NSC 77371 BRN 1739073 Bromoacetamide BROMOACETAMIDE 2-BROMOACETAMIDE 2-Bromoacetamide 2-bromo-acetamid Acetamide, 2-bromo- 2-BROMOACETAMIDE pure 4-02-00-00530 (Beilstein Handbook Reference) |
CAS | 683-57-8 |
EINECS | 614-427-0 |
InChI | InChI=1/C2H4BrNO/c3-1-2(4)5/h1H2,(H2,4,5) |
Molecular Formula | C2H4BrNO |
Molar Mass | 137.96 |
Density | 1.4243 (rough estimate) |
Melting Point | 87-91°C(lit.) |
Boling Point | 271.6±23.0 °C(Predicted) |
Flash Point | 118.1°C |
Solubility | 160g/l |
Vapor Presure | 0.00638mmHg at 25°C |
Appearance | Crystallization |
Color | White |
BRN | 1739073 |
pKa | 14.79±0.40(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Refractive Index | 1.4740 (estimate) |
MDL | MFCD00008025 |
Physical and Chemical Properties |
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Risk Codes | R25 - Toxic if swallowed R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2923 8/PG 2 |
WGK Germany | 3 |
RTECS | AB4587000 |
FLUKA BRAND F CODES | 10 |
HS Code | 29241990 |
Hazard Note | Irritant |
Hazard Class | 8 |
Packing Group | III |
biological activity | 2-Bromoacetamide can inactivate alcohol dehydrogenase. |
production method | 1L(1.5, 8.5mol) ethyl bromoacetate was added into a three-necked flask, and mechanical stirring was installed, thermometer and separatory funnel. Cool to below -10 °c in an ice-salt bath; In addition, 10% L of aqueous ammonia is cooled in an ice-salt bath for use. Under strong stirring, keep the reaction temperature below -5 ℃, slowly drip the ice-cold ammonia water, and stir for 1H after all the addition, the crystals were filtered off while cold (150ml of ethyl bromoacetate was recovered from the filtrate). It was washed once with 42% ml of diethyl ether and air-dried to give G (yield) of flaky crystals having a melting point of> 85 °c. |